Tags

• PEI 1
• transfection 1
• mitochondria 1
• gene therapy 1
• review 1
• SNPs 1
• discrimination 1
• mismatch oligos 1
• melt curve 1
• mitochondrial 1
• MTS 1
• bioinformatics 1
• sverreauxi 2
• mitogenome 1
• annotation 6
• methpat 2
• methylation 2
• data release 1
• prophage 1
• timebomb 1
• forensics 1
• miseq 1
• ovolvulus 5
• oochengi 1
• hrm 1
• speciation 1
• jedwardsii 1
• popgen 3
• genome 9
• wolbachia 2
• variation 1
• ovulgaris 2
• microbiome 2
• tcircumcincta 1
• resistance 7
• plag1 1
• spermatogenesis 1
• hcontortus 11
• genetic map 2
• polyandry 2
• polyploidy 2
• cinopinata 1
• chromosomes 1
• copy number 1
• qPCR 1
• helminths 4
• genomes 2
• annotations 2
• comparative genomics 1
• genomics 3
• radseq 1
• phylogenomics 1
• backcross 1
• ivermectin 2
• refugia 1
• mitogenomics 1
• transmission zones 1
• rnaseq 2
• bias 2
• global diversity 1
• climate 1
• scereviseae 1
• antifungal 1
• defensins 1
• amplicons 2
• barseq 1
• assembly 5
• hmicrostoma 1
• dmedinensis 1
• population genetics 3
• kinship 1
• anthelmintics 1
• diagnostics 3
• molecular 1
• smansoni 6
• scrnaseq 1
• grasstree 1
• phylogee 1
• cjohnstoni 1
• award 4
• x-qtl 3
• drug resistance 6
• genetic mapping 4
• benzimidazole resistance 1
• ivermectin resistance 1
• praziquantel 2
• STH 3
• FEC 2
• drugs 1
• clinical trial 1
• ttrichuris 1
• population genomics 1
• ancient 1
• strongyloides 1
• new drugs 1
• H. contortus 1
• levamisole 1
• helminth 1
• curation 1
• nemabiome 1
• ITS2 1
• horse 1
• genome-skimming 1
• scRNAseq 1
• miracidium 1
• RNAseq 1
• lifecycle 1
• octopus 1
• paralarvae 1
• barcoding 1
• diet 1
• dimmitis 1

PEI

• Differential intracellular distribution of DNA complexed with polyethylenimine (PEI) and PEI-polyarginine PTD influences exogenous gene expression within live COS-7 cells

transfection

• Differential intracellular distribution of DNA complexed with polyethylenimine (PEI) and PEI-polyarginine PTD influences exogenous gene expression within live COS-7 cells

mitochondria

• Mitochondrial gene therapy an evaluation of strategies for the treatment of mitochondrial DNA disorders

gene therapy

• Mitochondrial gene therapy an evaluation of strategies for the treatment of mitochondrial DNA disorders

review

• Mitochondrial gene therapy an evaluation of strategies for the treatment of mitochondrial DNA disorders

SNPs

• Enhanced annealing of mismatched oligonucleotides using a novel melting curve assay allows efficient in vitro discrimination and restriction of a single nucleotide polymorphism

discrimination

• Enhanced annealing of mismatched oligonucleotides using a novel melting curve assay allows efficient in vitro discrimination and restriction of a single nucleotide polymorphism

mismatch oligos

• Enhanced annealing of mismatched oligonucleotides using a novel melting curve assay allows efficient in vitro discrimination and restriction of a single nucleotide polymorphism

melt curve

• Enhanced annealing of mismatched oligonucleotides using a novel melting curve assay allows efficient in vitro discrimination and restriction of a single nucleotide polymorphism

mitochondrial

• Evidence of evolutionary constraints on the sequence composition of mitochondrial matrix targeting sequences

MTS

• Evidence of evolutionary constraints on the sequence composition of mitochondrial matrix targeting sequences

bioinformatics

• Evidence of evolutionary constraints on the sequence composition of mitochondrial matrix targeting sequences

sverreauxi

• Outlier SNPs detect weak regional structure against a background of genetic homogeneity in the Eastern Rock Lobster, Sagmariasus verreauxi
• Low-coverage MiSeq next generation sequencing reveals the mitochondrial genome of the Eastern Rock Lobster, Sagmariasus verreauxi

mitogenome

• Low-coverage MiSeq next generation sequencing reveals the mitochondrial genome of the Eastern Rock Lobster, Sagmariasus verreauxi

annotation

• The genome sequence of the Australian filarial nematode, Cercopithifilaria johnstoni
• Assembled chromosomes of the blood fluke Schistosoma mansoni provide insight into the evolution of its ZW sex-determination system
• Complete representation of a tapeworm genome reveals chromosomes capped by centromeres, necessitating a dual role in segregation and protection
• Genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm
• Biology and genome of a newly discovered sibling species of Caenorhabditis elegans
• Low-coverage MiSeq next generation sequencing reveals the mitochondrial genome of the Eastern Rock Lobster, Sagmariasus verreauxi

methpat

• MethPat: a tool for the analysis and visualisation of complex methylation patterns obtained by massively parallel sequencing
• Exemplary multiplex bisulfite amplicon data used to demonstrate the utility of Methpat

methylation

• MethPat: a tool for the analysis and visualisation of complex methylation patterns obtained by massively parallel sequencing
• Exemplary multiplex bisulfite amplicon data used to demonstrate the utility of Methpat

data release

• Exemplary multiplex bisulfite amplicon data used to demonstrate the utility of Methpat

prophage

• Locating and Activating Molecular ‘Time Bombs’: Induction of Mycolata Prophages

timebomb

• Locating and Activating Molecular ‘Time Bombs’: Induction of Mycolata Prophages

forensics

• Massively parallel sequencing of customised forensically informative SNP panels on the MiSeq

miseq

• Massively parallel sequencing of customised forensically informative SNP panels on the MiSeq

ovolvulus

• Utility of the Onchocerca volvulus mitochondrial genome for delineation of parasite transmission zones
• Reduced variation in Wolbachia density of larval stages in comparison with adults of Onchocerca volvulus: implications for clinical outcome of infection?
• Significant heterogeneity in Wolbachia copy number within and between populations of Onchocerca volvulus
• The genome of Onchocerca volvulus, agent of river blindness
• Discrimination between Onchocerca volvulus and O. ochengi filarial larvae in Simulium damnosum (s.l.) and their distribution throughout central Ghana using a versatile high-resolution speciation assay

oochengi

• Discrimination between Onchocerca volvulus and O. ochengi filarial larvae in Simulium damnosum (s.l.) and their distribution throughout central Ghana using a versatile high-resolution speciation assay

hrm

• Discrimination between Onchocerca volvulus and O. ochengi filarial larvae in Simulium damnosum (s.l.) and their distribution throughout central Ghana using a versatile high-resolution speciation assay

speciation

• Discrimination between Onchocerca volvulus and O. ochengi filarial larvae in Simulium damnosum (s.l.) and their distribution throughout central Ghana using a versatile high-resolution speciation assay

jedwardsii

• Outlier SNPs enable food traceability of the southern rock lobster, Jasus edwardsii

popgen

• The global diversity of Haemonchus contortus is shaped by human intervention and climate
• Outlier SNPs detect weak regional structure against a background of genetic homogeneity in the Eastern Rock Lobster, Sagmariasus verreauxi
• Outlier SNPs enable food traceability of the southern rock lobster, Jasus edwardsii

genome

• Genome structure and population genomics of the canine heartworm Dirofilaria immitis
• The genome sequence of the Australian filarial nematode, Cercopithifilaria johnstoni
• Assembled chromosomes of the blood fluke Schistosoma mansoni provide insight into the evolution of its ZW sex-determination system
• Population genomic evidence that human and animal infections in Africa come from the same populations of Dracunculus medinensis
• Complete representation of a tapeworm genome reveals chromosomes capped by centromeres, necessitating a dual role in segregation and protection
• Genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm
• Biology and genome of a newly discovered sibling species of Caenorhabditis elegans
• Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta
• The genome of Onchocerca volvulus, agent of river blindness

wolbachia

• Reduced variation in Wolbachia density of larval stages in comparison with adults of Onchocerca volvulus: implications for clinical outcome of infection?
• Significant heterogeneity in Wolbachia copy number within and between populations of Onchocerca volvulus

variation

• Significant heterogeneity in Wolbachia copy number within and between populations of Onchocerca volvulus

ovulgaris

• Genome-wide sequencing uncovers cryptic diversity and mito-nuclear discordance in the Octopus vulgaris species complex
• You Are What You Eat: A Genomic Analysis of the Gut Microbiome of Captive and Wild Octopus vulgaris Paralarvae and Their Zooplankton Prey

microbiome

• Worms and bugs of the gut: the search for diagnostic signatures using barcoding, and metagenomics–metabolomics
• You Are What You Eat: A Genomic Analysis of the Gut Microbiome of Captive and Wild Octopus vulgaris Paralarvae and Their Zooplankton Prey

tcircumcincta

• Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta

resistance

• The global diversity of Haemonchus contortus is shaped by human intervention and climate
• The confounding effects of high genetic diversity on the determination and interpretation of differential gene expression analysis in the parasitic nematode Haemonchus contortus
• Evaluation of DNA Extraction Methods on Individual Helminth Egg and Larval Stages for Whole-Genome Sequencing
• Refugia and anthelmintic resistance: Concepts and challenges
• Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus
• Genome-wide approaches to Investigate anthelmintic resistance
• Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta

plag1

• PLAG1 deficiency impairs spermatogenesis and sperm motility in mice

spermatogenesis

• PLAG1 deficiency impairs spermatogenesis and sperm motility in mice

hcontortus

• Genomic landscape of drug response reveals mediators of anthelmintic resistance
• Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and response to treatment in a parasitic nematode
• Genome-wide analysis of response to ivermectin treatment by a Swedish field population of Haemonchus contortus
• Phenotypic and genotypic analysis of benzimidazole resistance in reciprocal genetic crosses of Haemonchus contortus
• Genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm
• The global diversity of Haemonchus contortus is shaped by human intervention and climate
• The confounding effects of high genetic diversity on the determination and interpretation of differential gene expression analysis in the parasitic nematode Haemonchus contortus
• Evaluation of DNA Extraction Methods on Individual Helminth Egg and Larval Stages for Whole-Genome Sequencing
• Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus
• A Genome Resequencing-Based Genetic Map Reveals the Recombination Landscape of an Outbred Parasitic Nematode in the Presence of Polyploidy and Polyandry
• Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals genetic drift and soft selective sweeps contribute to loss of drug sensitivity

genetic map

• A Genome Resequencing-Based Genetic Map Reveals the Recombination Landscape of an Outbred Parasitic Nematode in the Presence of Polyploidy and Polyandry
• Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals genetic drift and soft selective sweeps contribute to loss of drug sensitivity

polyandry

• A Genome Resequencing-Based Genetic Map Reveals the Recombination Landscape of an Outbred Parasitic Nematode in the Presence of Polyploidy and Polyandry
• Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals genetic drift and soft selective sweeps contribute to loss of drug sensitivity

polyploidy

• A Genome Resequencing-Based Genetic Map Reveals the Recombination Landscape of an Outbred Parasitic Nematode in the Presence of Polyploidy and Polyandry
• Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals genetic drift and soft selective sweeps contribute to loss of drug sensitivity

cinopinata

• Biology and genome of a newly discovered sibling species of Caenorhabditis elegans

chromosomes

• Biology and genome of a newly discovered sibling species of Caenorhabditis elegans

copy number

• Reduced variation in Wolbachia density of larval stages in comparison with adults of Onchocerca volvulus: implications for clinical outcome of infection?

qPCR

• Reduced variation in Wolbachia density of larval stages in comparison with adults of Onchocerca volvulus: implications for clinical outcome of infection?

helminths

• Worms and bugs of the gut: the search for diagnostic signatures using barcoding, and metagenomics–metabolomics
• Refugia and anthelmintic resistance: Concepts and challenges
• Genome-wide approaches to Investigate anthelmintic resistance
• Comparative genomics of the major parasitic worms

genomes

• Improving helminth genome resources in the post-genomic era
• Comparative genomics of the major parasitic worms

annotations

• Improving helminth genome resources in the post-genomic era
• Comparative genomics of the major parasitic worms

comparative genomics

• Comparative genomics of the major parasitic worms

genomics

• Evaluation of genome skimming to detect and characterise human and livestock helminths
• Faecal egg counts and nemabiome metabarcoding highlight the genomic complexity of equine cyathostomin communities and provide insight into their dynamics in a Scottish native pony herd
• Genome-wide approaches to Investigate anthelmintic resistance

radseq

• Genome-wide sequencing uncovers cryptic diversity and mito-nuclear discordance in the Octopus vulgaris species complex

phylogenomics

• Genome-wide sequencing uncovers cryptic diversity and mito-nuclear discordance in the Octopus vulgaris species complex

backcross

• Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

ivermectin

• Ivermectin and albendazole coadministration: opportunities for strongyloidiasis control
• Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

refugia

• Refugia and anthelmintic resistance: Concepts and challenges

mitogenomics

• Utility of the Onchocerca volvulus mitochondrial genome for delineation of parasite transmission zones

transmission zones

• Utility of the Onchocerca volvulus mitochondrial genome for delineation of parasite transmission zones

rnaseq

• The confounding effects of high genetic diversity on the determination and interpretation of differential gene expression analysis in the parasitic nematode Haemonchus contortus
• Evaluation of DNA Extraction Methods on Individual Helminth Egg and Larval Stages for Whole-Genome Sequencing

bias

• The confounding effects of high genetic diversity on the determination and interpretation of differential gene expression analysis in the parasitic nematode Haemonchus contortus
• Evaluation of DNA Extraction Methods on Individual Helminth Egg and Larval Stages for Whole-Genome Sequencing

global diversity

• The global diversity of Haemonchus contortus is shaped by human intervention and climate

climate

• The global diversity of Haemonchus contortus is shaped by human intervention and climate

scereviseae

• Screening the Saccharomyces cerevisiae nonessential gene Deletion library reveals diverse mechanisms of action for antifungal plant defensins

antifungal

• Screening the Saccharomyces cerevisiae nonessential gene Deletion library reveals diverse mechanisms of action for antifungal plant defensins

defensins

• Screening the Saccharomyces cerevisiae nonessential gene Deletion library reveals diverse mechanisms of action for antifungal plant defensins

amplicons

• Phylogeographic patterns of the Australian grass trees (Xanthorrhoea Asphodelaceae) shown using targeted amplicon sequencing
• Screening the Saccharomyces cerevisiae nonessential gene Deletion library reveals diverse mechanisms of action for antifungal plant defensins

barseq

• Screening the Saccharomyces cerevisiae nonessential gene Deletion library reveals diverse mechanisms of action for antifungal plant defensins

assembly

• Population genomics of ancient and modern Trichuris trichiura
• The genome sequence of the Australian filarial nematode, Cercopithifilaria johnstoni
• Assembled chromosomes of the blood fluke Schistosoma mansoni provide insight into the evolution of its ZW sex-determination system
• Complete representation of a tapeworm genome reveals chromosomes capped by centromeres, necessitating a dual role in segregation and protection
• Genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm

hmicrostoma

• Complete representation of a tapeworm genome reveals chromosomes capped by centromeres, necessitating a dual role in segregation and protection

dmedinensis

• Population genomic evidence that human and animal infections in Africa come from the same populations of Dracunculus medinensis

population genetics

• Genome structure and population genomics of the canine heartworm Dirofilaria immitis
• Genome-wide analysis of Schistosoma mansoni reveals population structure and praziquantel drug selection pressure within Ugandan hot-spot communities
• Population genomic evidence that human and animal infections in Africa come from the same populations of Dracunculus medinensis

kinship

• Population genomic evidence that human and animal infections in Africa come from the same populations of Dracunculus medinensis

anthelmintics

• Challenges and opportunities for the adoption of molecular diagnostics for anthelmintic resistance

diagnostics

• Allele specific PCR for a major marker of levamisole resistance in Haemonchus contortus
• Worms and bugs of the gut: the search for diagnostic signatures using barcoding, and metagenomics–metabolomics
• Challenges and opportunities for the adoption of molecular diagnostics for anthelmintic resistance

molecular

• Challenges and opportunities for the adoption of molecular diagnostics for anthelmintic resistance

smansoni

• The stage- and sex-specific transcriptome of the human parasite Schistosoma mansoni
• A single-cell atlas of the free-living miracidium larva of Schistosoma mansoni
• Genome-wide analysis of Schistosoma mansoni reveals population structure and praziquantel drug selection pressure within Ugandan hot-spot communities
• A genetic TRP down the channel to praziquantel resistance
• Assembled chromosomes of the blood fluke Schistosoma mansoni provide insight into the evolution of its ZW sex-determination system
• Single-cell atlas of the first intra-mammalian developmental stage of the human parasite Schistosoma mansoni

scrnaseq

• Single-cell atlas of the first intra-mammalian developmental stage of the human parasite Schistosoma mansoni

grasstree

• Phylogeographic patterns of the Australian grass trees (Xanthorrhoea Asphodelaceae) shown using targeted amplicon sequencing

phylogee

• Phylogeographic patterns of the Australian grass trees (Xanthorrhoea Asphodelaceae) shown using targeted amplicon sequencing

cjohnstoni

• The genome sequence of the Australian filarial nematode, Cercopithifilaria johnstoni

award

• Congratulations to Marina on poster prize
• Anti-helmintics: Drugs, Resistance & Vaccines V
• New Cambridge Uni PhD student
• New Lab Website

x-qtl

• Genomic landscape of drug response reveals mediators of anthelmintic resistance
• Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and response to treatment in a parasitic nematode
• Phenotypic and genotypic analysis of benzimidazole resistance in reciprocal genetic crosses of Haemonchus contortus

drug resistance

• Genomic landscape of drug response reveals mediators of anthelmintic resistance
• Genome-wide analysis of Schistosoma mansoni reveals population structure and praziquantel drug selection pressure within Ugandan hot-spot communities
• Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and response to treatment in a parasitic nematode
• A genetic TRP down the channel to praziquantel resistance
• Genome-wide analysis of response to ivermectin treatment by a Swedish field population of Haemonchus contortus
• Phenotypic and genotypic analysis of benzimidazole resistance in reciprocal genetic crosses of Haemonchus contortus

genetic mapping

• Genomic landscape of drug response reveals mediators of anthelmintic resistance
• Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and response to treatment in a parasitic nematode
• Genome-wide analysis of response to ivermectin treatment by a Swedish field population of Haemonchus contortus
• Phenotypic and genotypic analysis of benzimidazole resistance in reciprocal genetic crosses of Haemonchus contortus

benzimidazole resistance

• Phenotypic and genotypic analysis of benzimidazole resistance in reciprocal genetic crosses of Haemonchus contortus

ivermectin resistance

• Genome-wide analysis of response to ivermectin treatment by a Swedish field population of Haemonchus contortus

praziquantel

• Genome-wide analysis of Schistosoma mansoni reveals population structure and praziquantel drug selection pressure within Ugandan hot-spot communities
• A genetic TRP down the channel to praziquantel resistance

STH

• Evaluation of genome skimming to detect and characterise human and livestock helminths
• An adaptive phase II/III safety and efficacy randomized controlled trial of single day or three-day fixed-dose albendazole-ivermectin co-formulation versus albendazole for the treatment of Trichuris trichiura and other STH infections. ALIVE trial protocol
• Worms and bugs of the gut: the search for diagnostic signatures using barcoding, and metagenomics–metabolomics

FEC

• Faecal egg counts and nemabiome metabarcoding highlight the genomic complexity of equine cyathostomin communities and provide insight into their dynamics in a Scottish native pony herd
• An adaptive phase II/III safety and efficacy randomized controlled trial of single day or three-day fixed-dose albendazole-ivermectin co-formulation versus albendazole for the treatment of Trichuris trichiura and other STH infections. ALIVE trial protocol

drugs

• An adaptive phase II/III safety and efficacy randomized controlled trial of single day or three-day fixed-dose albendazole-ivermectin co-formulation versus albendazole for the treatment of Trichuris trichiura and other STH infections. ALIVE trial protocol

clinical trial

• An adaptive phase II/III safety and efficacy randomized controlled trial of single day or three-day fixed-dose albendazole-ivermectin co-formulation versus albendazole for the treatment of Trichuris trichiura and other STH infections. ALIVE trial protocol

ttrichuris

• Population genomics of ancient and modern Trichuris trichiura

population genomics

• Population genomics of ancient and modern Trichuris trichiura

ancient

• Population genomics of ancient and modern Trichuris trichiura

strongyloides

• Ivermectin and albendazole coadministration: opportunities for strongyloidiasis control

new drugs

• Ivermectin and albendazole coadministration: opportunities for strongyloidiasis control

H. contortus

• Allele specific PCR for a major marker of levamisole resistance in Haemonchus contortus

levamisole

• Allele specific PCR for a major marker of levamisole resistance in Haemonchus contortus

helminth

• Improving helminth genome resources in the post-genomic era

curation

• Improving helminth genome resources in the post-genomic era

nemabiome

• Faecal egg counts and nemabiome metabarcoding highlight the genomic complexity of equine cyathostomin communities and provide insight into their dynamics in a Scottish native pony herd

ITS2

• Faecal egg counts and nemabiome metabarcoding highlight the genomic complexity of equine cyathostomin communities and provide insight into their dynamics in a Scottish native pony herd

horse

• Faecal egg counts and nemabiome metabarcoding highlight the genomic complexity of equine cyathostomin communities and provide insight into their dynamics in a Scottish native pony herd

genome-skimming

• Evaluation of genome skimming to detect and characterise human and livestock helminths

scRNAseq

• A single-cell atlas of the free-living miracidium larva of Schistosoma mansoni

miracidium

• A single-cell atlas of the free-living miracidium larva of Schistosoma mansoni

RNAseq

• The stage- and sex-specific transcriptome of the human parasite Schistosoma mansoni

lifecycle

• The stage- and sex-specific transcriptome of the human parasite Schistosoma mansoni

octopus

• Trophic ecology of Octopus vulgaris paralarvae along the Iberian Canary current eastern boundary upwelling system

paralarvae

• Trophic ecology of Octopus vulgaris paralarvae along the Iberian Canary current eastern boundary upwelling system

barcoding

• Trophic ecology of Octopus vulgaris paralarvae along the Iberian Canary current eastern boundary upwelling system

diet

• Trophic ecology of Octopus vulgaris paralarvae along the Iberian Canary current eastern boundary upwelling system

dimmitis

• Genome structure and population genomics of the canine heartworm Dirofilaria immitis